Study M550
Study name | Li KD 2019 |
Title | Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine |
Overall design | In this study, one of the gardenia blue pigments, was obtained from the reaction of genipin with tyrosine (genipin-tyrosine derivant (GTD)), and its antidepressant-like effects were investigated in chronic unpredictable mild stress (CUMS) models. Sprague-Dawley rats were divided into the following 4 groups (n = 8 per group): (1) control group, (2) CUMS group, (3) CUMS + genipin group (stressor plus genipin treatment at the dose of 50 mg/kg), and (4) CUMS + GTD group (stressor plus GTD treatment at the dose of 50 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered i.g. for 2 weeks after stress. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 32 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Shimadzu LC-20AD system coupled with a Sciex Qtrap 6500 mass spectrophotometer (SCIEX, USA); |
PMID | |
DOI | |
Citation | Li KD, Yan K, Wang QS, et al. Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine. Food Funct. 2019;10(8):4533-4545. |
Metabolite |
