Study M532
Study name | Cai HL 2019 |
Title | Quantitative monitoring of a panel of stress-induced biomarkers in human plasma by liquid chromatography-tandem mass spectrometry: an application in a comparative study between depressive patients and healthy subjects |
Overall design | In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously determine a panel of biomarkers comprising choline, creatine, purinergic metabolites, neurosteroids, lysophosphatidylcholines, and phosphatidylethanolamines in human plasma. The established method was successfully applied to analyze the plasma samples from a small cohort of 30 patients with major depressive disorder (MDD group) and 30 matched healthy controls (control group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | Not reported |
Sample size | 60 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: ultrafast liquid chromatography system (Shimadzu, Kyoto, Japan) coupled to a 4000 QTRAP mass spectrometer (AB SCIEX, Foster City, CA, USA); |
PMID | |
DOI | |
Citation | Cai H, Cao T, Li N, et al. Quantitative monitoring of a panel of stress-induced biomarkers in human plasma by liquid chromatography-tandem mass spectrometry: an application in a comparative study between depressive patients and healthy subjects. Anal Bioanal Chem. 2019;411(22):5765-5777. |
Metabolite | Choline; LysoPC(16:0); Hypoxanthine; Uric acid; |
