Study M531
Study name | Bhattacharyya S 2019 |
Title | Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients |
Overall design | In this study, the authors used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on a set of 31 metabolites from neurotransmitter-related pathways. Overall, 290 unipolar patients with major depressive disorder were profiled at baseline, after 4 and 8 weeks of drug treatment. Plasma samples were used for targeted metabolomics. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 14 |
Sample size | 290 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LCECA: Liquid chromatography electrochemical array (LCECA); |
PMID | |
DOI | |
Citation | Bhattacharyya S, Ahmed AT, Arnold M, et al. Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients. 2019;9(1):173. |
Metabolite | Indoleacetic acid; |
