Study M529
Study name | Huang TY 2020 |
Title | Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women |
Overall design | In this study, cross-sectional data from three independent samples of postmenopausal women were analyzed, including women from the Women’s Health Initiative-Observational Study (WHI-OS, n = 926), the WHI-Hormone Trials (WHI-HT; n = 1,325), and the Nurses’ Health Study II Mind-Body Study (NHSII-MBS; n = 218). Positive depression status was defined as having any of the following: elevated depressive symptoms, antidepressant use, or depression history. Plasma metabolites were measured using liquid chromatography-tandem mass spectrometry (21 phosphatidylcholines, 7 lysophosphatidylethanolamines, 5 ceramides, 3 branched chain amino acids, and 9 neurotransmitters). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Elevated depressive symptoms, antidepressant use, or depression history |
Sample size | 2469 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS/MS: Shimadzu Nexera X2 U-HPLC to an Exactive Plus orbitrap mass spectrometer and a Q Exactive hybrid quadrupole orbitrap mass spectrometer; |
PMID | |
DOI | |
Citation | Huang T, Balasubramanian R, Yao Y, et al. Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women. Mol Psychiatry. 2020. |
Metabolite |
