Study M520
Study name | Baranyi A 2018 |
Title | Metabolomics approach in the investigation of depression biomarkers in pharmacologically induced immune-related depression |
Overall design | The aim of this study was to identify previously unrecognised biological pathways and biomarkers that might expand the inflammatory hypothesis of depression. Broad metabolomics analyses in plasma samples from 31 chronic hepatitis C-infected patients with and without immune-related depression (depressive HCV group, n = 10; non-depressive HCV group, n = 21) were carried out using the Absolute IDQ p180 kit-a targeted metabolomics approach of combined direct flow injection and liquid chromatography that measures acylcarnitines, amino acids, biogenic amines, glycerophospholipids, sphingolipids, and sugars. |
Study Type | Type1; |
Data available | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208238 |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | Clinical psychiatric interview diagnosed MDD |
Sample size | 31 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1100 liquid chromatography system with SCIEX4000 triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Baranyi A, Meinitzer A, Rothenhausler HB, et al. Metabolomics approach in the investigation of depression biomarkers in pharmacologically induced immune-related depression. PLoS One. 2018 Nov 29;13(11):e0208238. |
Metabolite |
