Study M511
Study name | Akimoto H 2019 |
Title | Changes in brain metabolites related to stress resilience: metabolomic analysis of the hippocampus in a rat model of depression |
Overall design | This study aimed to investigate the differences in the profiles of hippocampal metabolites between susceptible and resilient rats, and to identify a biomarker that can distinguish the two. Of the 39 rats, 21 were randomly allocated to the Stressed Group, and the remaining 18 were allocated to the unstressed Control Group. Stress-loaded rats were into susceptible and resilient types based on their sucrose preference values. Metabolomic analysis in the hippocampus were conducted (Control Group, n = 14; Resilient Group, n = 9; Susceptible Group, n = 8). The CMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar/ST rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 22 |
Tissue | Central; Brain; Hippocampus; |
Platform | NMR; NMR: Varian INOVA-700 NMR instrument; |
PMID | |
DOI | |
Citation | Akimoto H, Oshima S, Sugiyama T, et al. Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression. Behav Brain Res. 2019 Feb 1;359:342-352. |
Metabolite |
