Study M503
Study name | Carnevali L 2015 |
Title | Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats |
Overall design | The aim of this study was to examine cardiac activity in a rodent model of social stress-induced depression and investigated whether pharmacological inhibition of the enzyme fatty acid amide hydrolase (FAAH), which terminates signaling of the endocannabinoid anandamide, exerts antidepressant-like and cardioprotective effects. Male Wistar Kyoto rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) SDS group (social stress), (3) URB694 group (URB694 treatment at the dose of 0.1 mg/kg, i.p.), (4) SDS + URB694 group (URB694 treatment at the dose of 0.1 mg/kg, i.p.). The SDS stress procedure lasted for 5 weeks, and drugs were administered once per day during the last 3 weeks of model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar Kyoto rat; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; Central; Brain; Striatum; Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Carnevali L, Vacondio F, Rossi S, et al. Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. Eur Neuropsychopharmacol. 2015;25(11):2157-69. |
Metabolite |
