Study M500
Study name | Gobbi G 2005 |
Title | Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis |
Overall design | The aim of this study was to examine the impact of URB597 on emotional and hedonic behavior. Rats received single (0.1 mg/kg, i.p.) or repeated injections (0.1 mg/kg, i.p., once daily for 4 days) of URB597. Forced swim test (FST) was conducted to test the antidepressant-like activity of URB597. Brain regions of Wistar rats were dissected, and endocannabinoids were quantified by HPLC-mass spectrometry. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Forced swimming test |
Sample size | 36 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; Central; Brain; Midbrain; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Gobbi G, Bambico FR, Mangieri R, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A. 2005;102(51):18620-5. |
Metabolite |
