Study M479
Study name | Liu K 2018 |
Title | Metabolic changes associated with a rat model of diabetic depression detected by ex vivo H-1 nuclear magnetic resonance spectroscopy in the prefrontal cortex, hippocampus, and hypothalamus |
Overall design | To explore the mechanisms underpinning the pathogenesis of the disease, the authors used ex vivo 1H nuclear magnetic resonance spectroscopy and immunohistochemistry to investigate the main metabolic and pathological changes in various rat brain areas in an animal model of diabetic depression (DD). Rats were divided into the following 2 groups: (1) control group (n = 8), (2) diabetic depression group (n = 18). Rats in the diabetic depression group were injected intraperitoneally with streptozotocin and then subjected to the chronic unpredictable mild stress (CUMS) procedure for 4 weeks. 14 rats in the diabetic depression group and 6 control rats were decapitated and the brain was rapidly removed for acquiring 1H-NMR spectra. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 20 |
Tissue | Central; Brain; Hypothalamus; Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | NMR; NMR: Bruker Avance III 600 MHz NMR spectrometer; |
PMID | |
DOI | |
Citation | Liu K, Zhao L, Xu W, et al. Metabolic changes associated with a rat model of diabetic depression detected by ex vivo H-1 nuclear magnetic resonance spectroscopy in the prefrontal cortex, hippocampus, and hypothalamus. Neural Plast. 2018;:6473728. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; N-Acetyl-L-aspartic acid; |
