Study M463
Study name | Hu QC 2018 |
Title | Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex |
Overall design | In this study, we used chromatography-mass spectrometry-based (GC-MS) metabolomics to examine the metabolite changes induced by diterpene ginkgolides (DG) in the prefrontal cortex (PFC) of mice. Mice were divided into the following 3 groups: (1) control group (n = 9), (2) DG group (diterpene ginkgolides treatment at the dose of 12.18 mg/kg; n = 11), and (3) venlafaxine group (venlafaxine treatment at the dose of 16 mg/kg; n = 11). Drugs were administered injected intraperitoneally daily for 2 weeks. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test |
Sample size | 31 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Hu Q, Shen P, Bai S, et al. Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex. Neuropsychiatr Dis Treat. 2018;14:999-1011. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; Citric acid; Stearic acid; Palmitic acid; N-Acetyl-L-aspartic acid; L-Valine; L-Proline; L-Glutamic acid; L-Serine; L-Methionine; L-Alanine; L-Asparagine; L-Glutamine; L-Aspartic acid; Hippuric acid; Succinic acid; Oxalic acid; Ethanolamine; Taurine; Uracil; Creatine; Inosine; Cholesterol; L-Malic acid; Adenosine; Methylmalonic acid; Maleic acid; 3-Aminoisobutanoic acid; Malonic acid; Dehydroascorbic acid; Glycerol 3-phosphate; Trehalose 6-phosphate; D-Alanyl-D-alanine; O-Phosphoethanolamine; Lipoamide; Fosfomycin; Octanal; N-Acetylleucine; N-Methylhydantoin; Aminooxyacetic acid; Malonamide; Gallic acid; Dihydrocarveol, (+)-; |
