Study M459

Study name

Kuwano N 2018

Title

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: An exploratory pilot case-control study

Overall design

As an exploratory pilot case-control study, the authors examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naive major depressive disorder (MDD) patients, based on metabolome/lipidome analysis. Plasma tryptophan and its related metabolites and plasma lipid species were measured in first episode first-episode drug-naive MDD patients (depression group, n = 15) and healthy controls (control group, n = 19) by liquid chromatography mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR diagnosed MDD

Sample size

34

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: LCMS-8040 (Shimadzu Corp., Kyoto, Japan);

MS-based; LC-MS: triple quadrupole mass spectrometer LCMS-8060 (Shimadzu Corp., Kyoto, Japan);

PMID

29454180

DOI

10.1016/j.jad.2018.01.014

Citation

Kuwano N, Kato TA, Setoyama D, et al. Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study. J Affect Disord 2018;231:74-82.

Metabolite

L-Tryptophan;

L-Kynurenine;