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Study M458

Study name

Kawamura N 2018

Title

Plasma metabolome analysis of patients with major depressive disorder

Overall design

The aim of this study was to characterize the plasma metabolite profiling of patients with major depressive disorder (MDD). In the exploratory cohort, plasma metabolite profiles of MDD patients (depression group, n = 34) and mentally healthy controls (control group, n = 31) were compared using capillary electrophoresis-mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR diagnosed MDD

Sample size

65

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; CE-MS: capillary-electrophoresis time-of-flight mass spectrometer (CE-TOF-MS);

PMID

29356314

DOI

10.1111/pcn.12638

Citation

Kawamura N, Shinoda K, Sato H, et al. Plasma metabolome analysis of patients with major depressive disorder. Psychiatry Clin Neurosci 2018.

Metabolite

L-Phenylalanine;

L-Methionine;

L-Asparagine;

L-Aspartic acid;

L-Lysine;

L-Tyrosine;

Taurine;

Hypotaurine;

L-Histidine;

Adenosine triphosphate;

Glycerophosphocholine;

Aminoadipic acid;

ADP;

O-Phosphoethanolamine;

Asymmetric dimethylarginine;