Study M446

Study name

Uzunova V 1998

Title

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

Overall design

In this study, ALLO content was measured in four cisternal-lumbar fractions of cerebrospinal fluid (CSF) before and 8-10 weeks after treatment with fluoxetine (0.27-1.5 mg per kg per day) or fluvoxamine (0.54-2.88 mg per kg per day) in 15 patients with unipolar major depression (depressed group). In addition, the CSF content of ALLO was also measured in 3 normal subjects (control group). Neurosteroids were quantified using GC/MS.

Study Type

Type1;

Type2;

Data available

http://www.pnas.org/content/95/6/3239.long

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-III-R diagnosed depression, HAMD-21 >= 20

Sample size

18

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Platform

MS-based; GC-MS: Hewlett-Packard model 5890 gas chromatograph with Hewlett-Packard 5988-B mass spectrometer;

PMID

9501247

DOI

N/A

Citation

Uzunova V, Sheline Y, Davis JM, et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci U S A 1998;95(6):3239-44.

Metabolite

Allopregnanolone;