Study M340
Study name | Gabbay V 2017 |
Title | Anterior cingulate cortex gamma-aminobutyric acid deficits in youth with depression |
Overall design | The aim of this study was to confirm the prior finding of decreased brain gamma-aminobutyric acid (GABA) in youth with major depressive disorder (MDD) and explore its associations with clinical variables. Psychotropic medication-free youth with MDD (depression group, n = 44) and healthy control (control group, n = 36) participants (12-21 years) were studied. Participants represent a combined sample of 39 newly recruited youth (MDD = 24) and 41 youth from our previously reported study (MDD = 20). GABA levels and the combined resonances of glutamate and glutamine (Glx) were measured in vivo in the anterior cingulate cortex using proton magnetic resonance spectroscopy. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, CDRS-R >= 35 |
Sample size | 80 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3.0 Tesla General Electric Excite HD MRI system (GE Medical Systems); |
PMID | |
DOI | |
Citation | Gabbay V, Bradley KA, Mao X, et al. Anterior cingulate cortex gamma-aminobutyric acid deficits in youth with depression. Transl Psychiatry 2017;7(8):e1216. |
Metabolite |
