Study M328

Study name

Wang ZS 2016

Title

GABA+ levels in postmenopausal women with mild-to-moderate depression: a preliminary study

Overall design

This study aimed to explore in vivo gamma-aminobutyric acid (GABA) levels in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and posterior-cingulate cortex (PCC) of postmenopausal women with depression using magnetic resonance spectroscopy (H-MRS). Postmenopausal women with depression (depression group, n = 19) and healthy controls (control group, n = 13) were enrolled in the study. All subjects underwent H-MRS of the ACC/mPFC and PCC using the "MEGA Point Resolved Spectroscopy Sequence" (MEGA-PRESS) technique. The severity of depression was assessed by 17-item Hamilton Depression Scale (HAMD). Quantification of MRS data was performed using Gannet program. Differences of GABA+ levels from patients and controls were tested using one-way analysis of variance. Spearman correlation coefficients were used to evaluate the linear associations between GABA+ levels and HAMD scores, as well as estrogen levels.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Postmenopausal depression; Postmenopausal depression;

Criteria for depression

ICD-10 diagnosed MDD

Sample size

32

Tissue

Central; Brain; Anterior cingulate cortex/medial prefrontal cortex;

Central; Brain; Posterior cingulate cortex;

Platform

MRS; MRS: 3.0 Tesla scanner (Philips "Achieva" TX, Best, The Netherlands);

PMID

27684829

DOI

10.1097/MD.0000000000004918

Citation

Wang Z, Zhang A, Zhao B, et al. GABA+ levels in postmenopausal women with mild-to-moderate depression: a preliminary study. Medicine 2016;95(39):e4918.

Metabolite

Gamma-Aminobutyric acid;