Study M270
Study name | Price RB 2009 |
Title | Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder |
Overall design | The objective of this study was to compare occipital cortex (OCC) and anterior cingulate cortex (ACC) GABA and glutamate + glutamine (Glx) levels measured by proton magnetic resonance spectroscopy (1H MRS) in medication-free treatment-resistant depression (TRD, n = 15) patients with those in nontreatment-resistant MDD (nTRD group, n = 18) patients and healthy volunteers (control group, n = 24). Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 57 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 3.0 T GE EXCITE MR system (General Electric Medical Systems, Waukesha, Wisconsin); |
PMID | |
DOI | |
Citation | Price RB, Shungu DC, Mao X, et al. Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry 2009;65(9):792-800. |
Metabolite |
