Study M254
Study name | Hasler G 2007 |
Title | Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy |
Overall design | The aim of this study was to measure glutamate/glutamine (Glx) and GABA levels in 2 regions of the prefrontal brain tissue in unmedicated adults with major depressive disorder (MDD). Unmedicated, depressed patients with MDD (depression group, n = 20) and age- and sex-matched controls (control group, n = 20). Participants underwent scanning using a 3-T whole-body scanner with a transmit-receive head coil, providing a homogeneous radiofrequency field and the capability of obtaining spectroscopic measurements in a dorsomedial/dorsal anterolateral prefrontal region of interest (ROI) and a ventromedial prefrontal ROI. Glx and GABA levels derived from magnetic resonance spectroscopy signals were compared for the two groups. The concentrations of GABA, choline, N-acetylaspartate (NAA), and coedited Glx (ie, glutamate and glutamine) are expressed in millimoles per liter referenced to the concentration of creatine that was set at 93mg/dL(7100umol/L). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, MADRS > 18 |
Sample size | 40 |
Tissue | Central; Brain; Ventromedial prefrontal; Central; Brain; Dorsomedial/dorsal anterolateral prefrontal; |
Platform | MRS; MRS: 3-T whole-body scanner (General Electric Medical Systems, Milwaukee, Wis); |
PMID | |
DOI | |
Citation | Hasler G, van der Veen JW, Tumonis T, et al. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 2007;64(2):193-200. |
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