Study M242
Study name | Sanacora G 2004 |
Title | Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression |
Overall design | The aim of this study was to replicate the GABA findings in a larger sample of major depressive disorder (MDD) patients, to examine the clinical correlates of the GABA reductions in these subjects, and to examine other critical metabolite levels. The GABA measurements were made on healthy control subjects (control group, n = 38) and depressed subjects (depression group, n = 33). Occipital cortex metabolite levels were measured using proton magnetic resonance spectroscopy. The levels of occipital cortex GABA, glutamate, N-acetyl aspartate, aspartate, creatine, and choline-containing compounds, along with several measures of tissue composition, were compared between the 2 groups. The concentrations were determined assuming a concentration of 9 mmol/kg for creatine. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 71 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 2.1-T magnet (Oxford Magnet Technology, Oxford, England) with spectrometer (Avance; Bruker Instruments, Billerica, Mass); |
PMID | |
DOI | |
Citation | Sanacora G, Gueorguieva R, Epperson CN, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 2004;61(7):705-13. |
Metabolite |
