Study M233
Study name | Kugaya A 2003 |
Title | Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT |
Overall design | The aim of this study was to investigate in vivo benzodiazepine (BZ) binding in unmedicated depressed patients compared with healthy subjects using single photon emission computed tomography (SPECT). Occipital GABA levels were determined by proton magnetic resonance spectroscopy (MRS) in unmedicated patients with unipolar major depression (depression group, n = 6). Male healthy control subjects (control group, n = 12) were matched to the six depressed patients. Metabolite quantification was reported relative to total creatine (9 mmol/kg wet weight) as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 18 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 2.1-T 1-m bore magnet (Oxford Magnet Technologies, Oxford, UK) with extensively modified Biospec I spectrometer (Bruker Instruments, Billerica, MA); |
PMID | |
DOI | |
Citation | Kugaya A, Sanacora G, Verhoeff NP, et al. Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT. Biol Psychiatry 2003;54(8):792-9. |
Metabolite |
