Study M231
Study name | Sanacora G 2003 |
Title | Increased cortical GABA concentrations in depressed patients receiving ECT |
Overall design | The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT. Ten subjects diagnosed with major depression and planning to receive treatment with ECT were enrolled in the study after providing written informed consent. Occipital cortex GABA concentrations in eight depressed patients were measured by using proton magnetic resonance spectroscopy before and after a course of ECT. Metabolite quantification was reported in absolute concentrations. The integral of the GABA peak was adjusted for the macromolecular contribution and compared with the total creatine signal for absolute quantification. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 8 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 2.1-T Oxford Magnet with Bruker Avance spectrometer (Bruker Instruments, Billerica, Mass.); |
PMID | |
DOI | |
Citation | Sanacora G, Mason GF, Rothman DL, et al. Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry 2003;160(3):577-9. |
Metabolite |
