Study M226
Study name | Sanacora G 2002 |
Title | Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors |
Overall design | The aim of this study was to determine whether these occipital cortex GABA concentrations are altered after administration of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. By means of proton magnetic resonance spectroscopy, occipital cortex GABA concentrations were measured in 11 medication-free depressed patients before initiation of treatment with SSRI medications and after an average of 2 months of treatment. Of the final 11 subjects, eight received fluoxetine (mean dose = 23.8 mg/d, SD=7.9), and three received citalopram (mean dose = 26.7 mg/d, SD=4.7). The integral of the GABA peak was adjusted for the macromolecular contribution and compared to the total creatine signal for absolute quantification. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 11 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 2.1-T Oxford magnet with Bruker Avance spectrometer (Bruker Instruments, Billerica, Mass.); |
PMID | |
DOI | |
Citation | Sanacora G, Mason GF, Rothman DL, et al. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry 2002;159(4):663-5. |
Metabolite |
