Study M216
Study name | Sanacora G 1999 |
Title | Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy |
Overall design | In this study, in vivo proton magnetic resonance spectroscopy was used to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression. The GABA levels were measured in the occipital cortex of medication-free depressed patients meeting DSM-IV criteria (depression group, n = 14) and healthy control subjects with no history of mental illness (control group, n = 18) using a localized difference editing proton magnetic resonance spectroscopy protocol. Metabolite quantification was reported relative to total creatine (9 mmol/kg wet weight) as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 32 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 2.1 T Oxford Magnet (Oxford Magnetic Technology, Oxford, England) with Bruker Biospec Avance I spectrometer (Bruker Instruments, Billerica, Mass); |
PMID | |
DOI | |
Citation | Sanacora G, Mason GF, Rothman DL, et al. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 1999;56(11):1043-7. |
Metabolite |
