Study M193
Study name | Sartorius A 2007 |
Title | Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness |
Overall design | In this study, the effect of alterations of gamma-aminobutyric acid (GABA) and glutamate (Glu) were investigated in the congenital learned helplessness (cLH) paradigm. Proton magnetic resonance spectroscopy is an important monitoring tool to bridge the findings in clinical and preclinical studies. Rats were divided into the following 6 groups: (1) control group (outbred SD rats treated with saline, n = 8), (2) desipramine group (outbred SD rats treated with desipramine at the dose of 10 mg/kg, n = 10), (3) ECS group (outbred SD rats treated with electroconvulsive shocks, n = 8), (4) cLH group (cLH rats treated with saline, n = 5), (5) cLH + desipramine group (cLH rats treated with desipramine at the dose of 10 mg/kg, n = 5), and (6) cLH + ECS group (cLH rats treated with electroconvulsive shocks (ECS), n = 6). Desipramine was treated for 4 weeks with daily intraperitoneal injections. The ECS group received a 4-week course of ECS, administered three times per week. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Learned helplessness model; Learned helplessness model; |
Criteria for depression | Active escape test |
Sample size | 42 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | NMR; NMR: 9.4 T Bruker AVC400 spectrometer (Bruker BioSpin GmbH, Silberstreifen, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Sartorius A, Mahlstedt MM, Vollmayr B, et al. Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. Neuroreport 2007;18(14):1469-73. |
Metabolite |
