Study M192
Study name | Marsteller DA 2007 |
Title | Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels |
Overall design | In this study, 2-week and 4-week citalopram infusion (10 mg/kg/day) were used to determine how this selective serotonin reuptake inhibitor (SSRI) would alter 2-deoxy-2-[18F]-fluoro-D-glucose (18FDG) uptake and neurotransmitter tissue levels in male Sprague-Dawley rodents. Twelve rats were divided into the following 3 groups: (1) control group (implanted with a pump filled with dH2O 2.5 ul/h/28 days), (2) 2-week citalopram group (implanted with a pump filled with 49 mg citalopram/2 ml dH2O infused 5 ul/h/14 days) resulting in 10 mg/kg daily infusion of citalopram for 2 weeks based on a 350 g body weight), (3) 4-week citalopram group (implanted with a pumpfilled with 98 mg citalopram/2 ml dH2O infused 2.5 ul/h/28 days, resulting in 10 mg/kg daily citalopram for 4 weeks based on a 350 g body weight). End of study monoamine levels were measured ex vivo using high pressure liquid chromatography (HPLC) and amino acid levels were determined ex vivo with proton nuclear magnetic resonance spectroscopy (1H-NMRS). |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 12 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Striatum; |
Platform | NMR; NMR: 9.4 T Bruker AVANCE 400 MHz spectrometer; |
PMID | |
DOI | |
Citation | Marsteller DA, Barbarich-Marsteller NC, Patel VD, et al. Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels. Synapse 2007;61(11):877-81. |
Metabolite |
