Study M190
Study name | Krause DL 2012 |
Title | Effects of antidepressants and cyclooxygenase-2 inhibitor on cytokines and kynurenines in stimulated in vitro blood culture from depressed patients |
Overall design | In this study, the effects of anti-inflammatory medication and antidepressants on cytokines and tryptophan metabolite changes in blood culture with immune challenge [bacterial mimetic lipopolysaccharide (LPS)] were investigated. Depressed patients (depressed group, n = 21) and matched controls (control group, n = 38) were recruited. Whole blood cultures were stimulated with LPS and drugs were added (celecoxib, venlafaxine, reboxetine, imipramine and fluoxetine). Tryptophan metabolites (tryptophan, kynurenine, 3-hydroxykynurenine and kynurenic acid) were analysed using UPLC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 59 |
Tissue | Peripheral; Blood; Whole blood culture; |
Platform | MS-based; LC-MS: Water AQUITY UPLC (TM) system with Waters Xevotm tandem quadrupole mass spectrometer (Waters Corp., Milford, MA, USA); |
PMID | |
DOI | |
Citation | Krause DL, Riedel M, Müller N, et al. Effects of antidepressants and cyclooxygenase-2 inhibitor on cytokines and kynurenines in stimulated in vitro blood culture from depressed patients. Inflammopharmacology 2012;20(3):169-76. |
Metabolite |
