Study M184
Study name | Clark SM 2016 |
Title | Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals |
Overall design | In this study, the authors conducted a postmortem analysis of kynurenine pathway metabolite levels and the expression of kynurenine pathway enzymes in the ventrolateral prefrontal cortex (VLPFC) of control and depressed individuals whose deaths had resulted from suicide or other causes. A sample set from 81 individuals, corresponding to 36 controls (control group) and 45 who had a diagnosis of depressive disorder not otherwise specified (depressed group) was used for analysis. Tryptophan, kynurenine and quinolinic acid levels in the brain were analyzed using GC/MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed depressive disorder not otherwise specified |
Sample size | 81 |
Tissue | Central; Brain; Ventrolateral prefrontal cortex; |
Platform | MS-based; GC-MS: 7890A GC with 7000 MS/MS (Agilent Technologies); |
PMID | |
DOI | |
Citation | Clark SM, Pocivavsek A, Nicholson JD, et al. Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals. J Psychiatry Neurosci 2016;41(6):386-94. |
Metabolite |
