Study M181

Study name

Bai SJ 2017b

Title

Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine

Overall design

In this study, we used depression-related behavior to evaluate the effects of chronic venlafaxine therapy in rats. Gas chromatography mass spectrometry-based metabolomics was used to characterize metabolomic responses to venlafaxine in the hippocampus and prefrontal cortex. Rats were divided into the following 2 groups (n = 14 in each group): (1) control group, and (2) venlafaxine group (venlafaxine treatment at the dose of 5 mg/kg). Venlafaxine were administered intraperitoneally daily for 4 weeks.

Study Type

Type3;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Forced swimming test, tail suspension test

Sample size

28

Tissue

Central; Brain; Hippocampus;

Central; Brain; Prefrontal cortex;

Platform

MS-based; GC-MS: Agilent 7890A/5975C GC/MSD System (Agilent Technologies, Santa Clara, California, USA);

PMID

N/A

DOI

10.1039/c7ra08726h

Citation

Bai S, Hu Q, Chen Z, et al. Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine. RSC Adv 2017,7, 46358.

Metabolite

myo-Inositol;

Citric acid;

Phosphoserine;

Oleic acid;

Stearic acid;

3-Hydroxybutyric acid;

Palmitic acid;

Glycine;

Arachidonic acid;

L-Glutamine;

L-Aspartic acid;

Oxalic acid;

D-Glucose;

Ascorbic acid;

Fumaric acid;

Fructose 6-phosphate;

Ethanolamine;

Creatine;

2-Hydroxybutyric acid;

D-Ribose;

Beta-Alanine;

5-Methoxytryptamine;

Glycolic acid;

Elaidic acid;

Fructose 1,6-bisphosphate;

Adenine;

Sucrose;

Malonic acid;

Oxamate;

Ribitol;

Aminomalonic acid;

6-Phosphogluconic acid;

Phosphate;

O-Phosphoethanolamine;

D-Tagatose;

Maleimide;

N-acetyltryptophan;

2-Hydroxypyridine;

Methyl palmitoleate;

11Z-Eicosenoic acid;

N-Methylhydantoin;

Sphingosine;

Aminooxyacetic acid;

Mannitol;

Methylphosphate;

Aniline;

Beta-mannosylglycerate;

3-Indoleacetonitrile;

Nicotinuric acid;

Cysteinylglycine;

Malonamide;

Monoethylhexyl phthalic acid;

Phytanic acid;

Kyotorphin;

Glycerol 1-octadecanoate;

Gallic acid;

MALONAMIDE;

Dithioerythritol;

Quinone;

Mevalonolactone;

Phenylglyoxylic acid;

Methyl linoleate;

Prostaglandin E2;

Erythrono-1,4-lactone;

2-Ketobutyric acid;

Pantothenol;

(2E)-Decenoyl-ACP;