Study M174
Study name | Hill M 2016 |
Title | Circulating C19 steroids and progesterone metabolites in women with acute depression and anxiety disorders |
Overall design | The aim of this study was to obtain data on alterations in circulating steroids and related substances such as gonadotropins and sex hormone binding globulin (SHBG) in female patients with acute depression and anxiety disorders, using quantification of the steroid metabolome in circulation by gas chromatography mass spectrometry (GC-MS). Twenty women with depression (depression group), 17 with anxiety disorders (anxiety group), 17 healthy controls (control group) were recruited. In addition to age-adjusted analysis of covariance (ANCOVA) followed by multiple comparisons, models were developed to successfully discriminate these groups from each other on the basis of steroid levels. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD, Clinical Global Impressions (CGI) scale >= 4 |
Sample size | 39 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: GCMS-QP2010 Plus system by Shimadzu (Kyoto, Japan); |
PMID | |
DOI | |
Citation | Hill M, Ripova D, Mohr P, et al. Circulating C19 steroids and progesterone metabolites in women with acute depression and anxiety disorders. Horm Mol Biol Clin Investig 2016;26(3):153-64. |
Metabolite | Allopregnanolone; Dehydroepiandrosterone; Epiandrosterone; 5-Androstenediol; Pregnenolone sulfate; Delta5-pregnenediol; 20alpha-Dihydropregnenolone sulfate; Dehydroepiandrosterone sulfate; 16a-Hydroxydehydroisoandrosterone; 16a-hydroxy DHEA 3-sulfate; Androstenediol sulfate; 5-Androstene-3b,7a,17b-triol; Estrone sulfate; Allopregnanolone Sulfate; Isopregnanolone sulfate; Pregnanolone; 3alpha-hydroxy-5beta-pregnan-20-one; Pregnanediol; 3beta,5beta,20alpha-pregnanediol; Epiandrosterone Sulfate; Etiocholanolone sulfate; Epietiocholanolone; Dihydroandrosterone; 5alpha-Androstane-3beta,17beta-diol; 3alpha,5alpha-tertra-hydro-progesterone; |
