Study M162
Study name | Mann JJ 2014 |
Title | Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid |
Overall design | The aim of this study was to investigate the relationship of cerebrospinal fluid (CSF) free GABA to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Patients with a DSM-IV major depressive episode (n = 167: 130 major depressive disorder; 37 bipolar disorder) and healthy volunteers (n = 38) had CSF free GABA measured by gas chromatography mass spectroscopy. Symptomatology was assessed by Hamilton depression rating scale. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed major depressive episode |
Sample size | 168 |
Tissue | Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; GC-MS: HP 5988B gas chromatography-mass spectrometer; |
PMID | |
DOI | |
Citation | Mann JJ, Oquendo MA, Watson KT, et al. Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid. Depress Anxiety 2014;31(10):814-21. |
Metabolite |
