Study M160
Study name | Chen SD 2014 |
Title | Effects of Chaiyuwendan decoction on endocannabinoids levels in adipose tissue of rats with chronic stress-induced depression |
Overall design | The aim of this study was to investigate how Chaiyuwendan decoction (CWD) affects endocannabinoid levels in the adipose tissue of depressed rats. Rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + CWD group (stressor plus Chaiyuwendan decoction treatment at the dose of 12.5 g/kg), and (4) CUMS + amitriptyline group (stressor plus amitriptyline treatment at the dose of 100 mg/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were administered via intragastric once per day during the model building period. The levels of AEA (N-arachidonoylethanolamine), 2-AG (2-arachidonoylglycerol), and PEA (N-palmitoylethanolamine) in rat adipose tissue were determined with liquid chromatography-mass spectrometry. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 24 |
Tissue | Peripheral; Adipose tissue; Adipose tissue; |
Platform | MS-based; LC-MS: Agilent 1100 (Shanghai, China); |
PMID | |
DOI | |
Citation | Chen S, Zhao X, Lu F, et al. Effects of Chaiyuwendan decoction on endocannabinoids levels in adipose tissue of rats with chronic stress-induced depression. J Tradit Chin Med 2014;34(1):96-9. |
Metabolite |
