Study M159

Study name

Erhardt S 2013

Title

Connecting inflammation with glutamate agonism in suicidality

Overall design

The aim of this study was to measure quinolinic acid (QUIN) in the cerebrospinal fluid (CSF) of 64 medication-free suicide attempters and 36 controls, using gas chromatography mass spectrometry. Patients were assessed clinically using the Suicide Intent Scale and the Montgomery-Asberg Depression Rating Scale (MADRS). Age-corrected QUIN was compared between healthy controls (control group; n= 36), suicide attempters with a diagnosis of a primary mood disorder (major depressive disorder and depression NOS, depressed group; n= 31).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression with suicide; Depression with suicide;

Criteria for depression

DSM-IIIR diagnosed MDD and depression NOS

Sample size

67

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Platform

MS-based; GC-MS: Agilent 6890 gas chromatograph with Agilent 5973 mass selective detector;

PMID

23299933

DOI

10.1038/npp.2012.248

Citation

Erhardt S, Lim CK, Linderholm KR, et al. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 2013;38(5):743-52.

Metabolite

Quinolinic acid;