Study M144
Study name | Zhang W 2017 |
Title | [Antidepressant effect and mechanism of Gross saponins of Tribulus terrestris] |
Overall design | The aim of this study was to study the antidepressant effect and mechanism of Gross saponins of Tribulus terrestris (GSTT). The model of depression was established by unpredictable chronic mild stress (UCMS), then open field test (OFT) and tail suspension test (TST) were used to evaluate the behavioral changes. LC-MS/MS method was employed to measure blood neurotransmitters. All the rats were divided into the following 6 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 1 mg/kg), (4) CUMS + low dose of GSTT group (stressor plus Gross saponins of Tribulus terrestris treatment at the dose of 31.25 mg/kg), (5) CUMS + middle dose of GSTT group (stressor plus Gross saponins of Tribulus terrestris treatment at the dose of 62.5 mg/kg), and (6) CUMS + high dose of GSTT group (stressor plus Gross saponins of Tribulus terrestris treatment at the dose of 125 mg/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were administered via intragastric once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Tail suspension test |
Sample size | 48 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1290 HPLC system with Agilent 6410 triple stage quadrupole mass spectrometer (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Zhang W, Yu Z, Mei T, et al. Antidepressant effect and mechanism of Gross saponins of Tribulus terrestris. Chinese Pharmacological Bulletin 2017; 33(3):343-8. (Article in Chinese) |
Metabolite |
