Study M134
Study name | Li JJ 2014 |
Title | [Metabonomics study on antidepressant effect of Banxia-houpo decoction] |
Overall design | Partial Least Squares analysis methods were used to characterize rat urine obtained after chromic exposure Banxia-Houpo decoction. A LC-MS-based urinary metabolomics method was applied to evaluate the efficacy of Banxia-Houpo decoction (BH) on rat model of chronic restraint stress (CRS). Rats were divided into 3 groups (n = 5 in each group): (1) control group, (2) CRS group (restraint stress for 6 hours daily), (3) CRS + BH group (restraint stress plus Banxia-Houpo decoction at the dose of 6.32 g/kg). The CRS stress procedure lasted for 24 days, and drugs were administered by gastric intubation every other day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test |
Sample size | 15 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Agilent 1260 LC system with 6410 triple quadrupole tandem mass spectrometer (Agilent Technologies Co.); |
PMID | |
DOI | |
Citation | Li J, Lin S, Guo C, et al. [Metabonomics study on antidepressant effect of Banxia-houpo decoction]. Science Technology and Engineering 2014;14(28):22-6. (Article in Chinese) |
Metabolite | Citric acid; L-Phenylalanine; L-Tryptophan; |
