Study M132

Study name

Zheng XY 2010

Title

[Evaluation on stress animal models of depression based on metabonomics]

Overall design

The aim of this study was to evaluate the chronic unpredictable mild stress (CUMS) model and chronic restraint stress (CRS) model based on metabonomics using NMR. Rats were divided into 3 groups (n = 6 in each group): (1) control group (no stress and no drug), (2) CUMS group (chronic unpredictable mild stress model), (3) CRS group (chronic restraint stress model). Taking open-field test, body weight, and sucrose preference test as general indexes during the experimental period, the 21d urine samples were analyzed by NMR. The CUMS and CRS stress procedure lasted for 3 weeks.

Study Type

Type1;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Chronic restraint stress model; Chronic restraint stress model;

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test

Sample size

18

Tissue

Peripheral; Urine; Urine;

Platform

NMR; NMR: Bruker Avance-300 DRX NMR system;

PMID

N/A

DOI

N/A

Citation

Zheng X, Gao X, Liu X, et al. [Evaluation on stress animal models of depression based on metabonomics]. Drug Evaluation Research 2010;33(3):175-9. (Article in Chinese)

Metabolite

L-Valine;

L-Leucine;

L-Proline;

Glycine;

L-Isoleucine;

L-Asparagine;

L-Tyrosine;

L-Arginine;

Creatine;