Study M129
Study name | Shen P 2017 |
Title | Venlafaxine exerts antidepressant effects possibly by activating MAPK-ERK1/2 and P13K-AKT pathways in the hippocampus |
Overall design | Here, we explored the potential biological effects of venlafaxine on mouse hippocampus. Mice were randomly divided into two groups and injected daily with 0.9% NaCl solution or venlafaxine. A GC-MS-based metabolomic approach was used to identify possible metabolic differences between these groups, and the key proteins involved in the relevant pathways were validated by western blotting. Mice were divided into 2 groups: (1) control group (saline treatment; n = 9), (2) venlafaxine group (venlafaxine treatment at the dose of 16 mg/kg; n = 11). Venlafaxine was administered intraperitoneally daily for 14 days. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: GC 7890A/5975C system (Agilent Co.); |
PMID | |
DOI | |
Citation | Shen P, Hu Q, Dong M, et al. Venlafaxine exerts antidepressant effects possibly by activating MAPK-ERK1/2 and P13K-AKT pathways in the hippocampus. Behav Brain Res 2017;335:63-70. |
Metabolite | Gamma-Aminobutyric acid; Citric acid; Stearic acid; Palmitic acid; N-Acetyl-L-aspartic acid; Glycine; L-Alanine; L-Asparagine; L-Glutamine; L-Aspartic acid; L-Tyrosine; Oxalic acid; Urea; DOPA; Inosine; Norepinephrine; L-Malic acid; Pyrophosphate; Dehydroascorbic acid; Glycerol 3-phosphate; Phosphate; O-Phosphoethanolamine; |
