Study M119

Study name

Zhou XY 2017

Title

Metabolomics identifies perturbations in amino acid metabolism in the prefrontal cortex of the learned helplessness rat model of depression

Overall design

In this study, a non-targeted gas chromatography-mass spectrometry-based metabolomics approach was used to investigate metabolic changes in the prefrontal cortex of the learned helplessness (LH) rat model of depression. Rats were divided into 2 groups: (1) control group, (2) LH group (learned helplessness model). Ten sample in the LH group and eight sample in the control group were used for metabonomic analysis. The LH stress procedure lasted for 3 weeks.

Study Type

Type1;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Learned helplessness model; Learned helplessness model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

18

Tissue

Central; Brain; Prefrontal cortex;

Platform

MS-based; GC-MS: Agilent 7890A/5975C GC/MSD System (Agilent Technologies, CA, USA);

PMID

27919695

DOI

10.1016/j.neuroscience.2016.11.038

Citation

Zhou X, Liu L, Zhang Y, et al. Metabolomics identifies perturbations in amino acid metabolism in the prefrontal cortex of the learned helplessness rat model of depression. Neuroscience 2017;343:1-9.

Metabolite

myo-Inositol;

Gamma-Aminobutyric acid;

L-Proline;

L-Methionine;

L-Alanine;

L-Glutamine;

Creatine;

Adenosine;

Trehalose 6-phosphate;

Phosphate;

N-Oleoyldopamine;

Fosfomycin;

N-acetyltryptophan;

N-Acetylleucine;

N-Methylhydantoin;

Cysteamine;

Aspirin;

Glycylproline;