Study M1141
Study name | Li NM 2023 |
Title | An integrated multi-level analysis reveals learning-memory deficits and synaptic dysfunction in the rat model exposure to austere environment |
Overall design | The aim of this study was to investigate the effects of austere environment on emotion and cognitive function in a rodent model. Sprague-Dawley rats were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) austere environment group. For the austere environment stress, stress stimulation includes noise, confinement, 10% O2, 6% CO2, 80% high humidity environment and high-temperature environment. After 21 days of austere environment stress, the rats exhibit depressive-like behavior and cognitive impairment. The levels of glutamate and gamma-aminobutyric acid in the hippocampus tissue were determined using LC-MS (n = 7-8 in each group). |
Study Type | Type1; |
Data available | |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 15 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1200 HPLC with Agilent 6490 MS/MS (Agilent, USA); |
PMID | |
DOI | |
Citation | Li N, Gao Y, Zhang Y, et al. An integrated multi-level analysis reveals learning-memory deficits and synaptic dysfunction in the rat model exposure to austere environment. J Proteomics. 2023 May 15;279:104887. |
Metabolite |
