Study M1129
Study name | An ZW 2023 |
Title | Hippocampal proteomics reveals the role of glutamatergic synapse activation in the depression induced by perfluorooctane sulfonate |
Overall design | The aim of this study was to examine the effect of perfluorooctane sulfonate exposure on depression in adult mice. Male C57BL/6J mice were divided into the following 3 groups (n = 8 in each group): (1) control group (vehicle treatment), (2) middle dose of perfluorooctane sulfonate group (perfluorooctane sulfonate treatment at the dose of 1.0 mg/kg), and (3) high dose of perfluorooctane sulfonate group (perfluorooctane sulfonate treatment at the dose of 3.0 mg/kg). The mice were administered various concentrations of perfluorooctane sulfonate orally for 12 weeks. The results of behavior tests showed that perfluorooctane sulfonate exposure led to depressive-like behaviors in male mice. Neurotransmitters and amino acid levels in the hippocampus were determined by LC-MS/MS (n = 5 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 15 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: AB SCIEX Triple Quad TM 4500MD; |
PMID | |
DOI | |
Citation | An Z, Yang J, Xiao F, et al. Hippocampal proteomics reveals the role of glutamatergic synapse activation in the depression induced by perfluorooctane sulfonate. J Agric Food Chem. 2023 May 24;71(20):7866-7877. |
Metabolite |
