Study M1103
Study name | Yao H 2022 |
Title | Gut microbiome and fecal metabolic alteration in systemic lupus erythematosus patients with depression |
Overall design | The aim of this study was to investigate fecal metabolic alteration in systemic lupus erythematosus (SLE) patients with depression. Twenty-one SLE patients with depression (SLE with depression group; Self-Rating Depression Scale >= 50), 17 SLE patients without depression (SLE without depression group; Self-Rating Depression Scale < 50), and 32 healthy controls (control group) were included in this study. Fecal samples were collected for ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Self-Rating Depression Scale >= 50 |
Sample size | 70 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Waters UPLC Acquity I-Class PLUS system with Waters Xevo G2-XS QTof High-resolution mass spectrometry; |
PMID | |
DOI | |
Citation | Yao H, Yang H, Wang Y, et al. Gut microbiome and fecal metabolic alteration in systemic lupus erythematosus patients with depression. Front Cell Infect Microbiol. 2022 Nov 25;12:1040211. |
Metabolite | L-Proline; Cholic acid; Alpha-Linolenic acid; 4-Hydroxynonenal; Stearidonic acid; 20-Hydroxyeicosatetraenoic acid; Adrenic acid; PC(O-16:0/20:3(8Z,11Z,14Z)); p-Menthan-3-ol; 2-Aminomuconic acid; Fexofenadine; N-Arachidonoyl tyrosine; alpha-Methylphenylalanine; D-Urobilinogen; Homoveratric acid; Ganglioside GA2 (d18:1/18:0); Austroinulin; 15-Oxo-lipoxin A4; PS(14:0/18:0); PC(20:4(5Z,8Z,11Z,14Z)/P-18:1(9Z)); (E, E)-11,13-Octadecadien-9-ynoic acid; Erysothiopine; Menthone 1,2-glyceryl ketal; 2-Hydroxy-6-tridecylbenzoic acid; Ligustilide; Miglustat; Dihydrojasmonic acid; 7',8'-Dihydro-8'-hydroxycitraniaxanthin; PC(14:0/18:3(6Z,9Z,12Z)); (S)-[8]-Gingerol; xi-4-Hydroxy-4-methyl-2-cyclohexen-1-one; Mepenzolate; Cotinine N-oxide; 12-hydroxyicosanoic acid; Riesling acetal; Tetrahydrocorticosterone; 6-Carboxy-5,6,7,8-tetrahydropterin; Jasmonic acid; Rutin; Mannitol 1-phosphate; |
