Study M110
Study name | Liu YY 2017 |
Title | Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats |
Overall design | Here, the social defeat stress paradigm was used to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors. Rats were divided into 2 groups: (1) control group (no stress, n = 8), and (2) SD group (social defeat model, n = 9). The social defeat stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 17 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC/MSD system (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Liu YY, Zhou XY, Yang LN, et al. Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats. PLoS One 2017;12(4):e0176725. |
Metabolite | Glycerol; Stearic acid; Palmitic acid; N-Acetyl-L-aspartic acid; Arachidonic acid; L-Asparagine; Succinic acid; L-Tyrosine; Ethanolamine; Uracil; Creatine; Glucose 1-phosphate; Methylmalonic acid; Benzoic acid; D-Threitol; Succinic acid semialdehyde; N-Ethylglycine; Maleimide; Octanal; |
