Study M1094
Study name | Zhang H 2023 |
Title | Profiling GABA(A) receptor subunit expression in the hippocampus of PMDD rat models based on TCM theories |
Overall design | The aim of this study was to explore patterns of hippocampal GABAAR subunit expression in rat models of premenstrual dysphoric disorder liver-qi depression syndrome. Female Wistar rats were divided into the following 2 groups: (1) control group, and (2) premenstrual dysphoric disorder liver-qi depression syndrome model group. Rats in the model group were subjected to ovariectomy, and allowed to recover for 1 to 2 weeks. Then rats were restrained for 8 days (6 h per day). Ultra-high performance liquid chromatography-tandem mass spectrometry analysis was performed to determine gamma-aminobutyric acid and glutamate levels in the hippocampus. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 6 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: SCIEX exionLC ultra-high-performance liquid chromatograph with SCIEX QTRAP 6500 mass spectrometer; |
PMID | |
DOI | |
Citation | Zhang H, Gao Z, Sun Y, et al. Profiling GABA(A) receptor subunit expression in the hippocampus of PMDD rat models based on TCM theories. Mol Neurobiol. 2023 Apr 27. |
Metabolite |
