Study M1082
Study name | Wang TT 2023b |
Title | Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism |
Overall design | The aim of this study was to determine whether 1-methyl-tryptophan improve depression-like behavior in the interferon gamma overdose induced depression. C57BL/6 J mice were divided into the following 4 groups (n = 10 in each group): (1) control group, (2) interferon gamma group (interferon gamma treatment), (3) interferon gamma + 1-methyl-tryptophan group (interferon gamma plus 1-methyl-tryptophan treatment at the dose of 15 mg/kg), and (4) interferon gamma + Pulsatilla chinensis saponins group (interferon gamma plus Pulsatilla chinensis saponins treatment at the dose of 100 mg/kg). Interferon gamma was administrated to mice by intraperitoneal injection at a dose of 7 × 10^4 U/kg/day for 21 days. Measurement of tryptophan and its metabolites levels were performed using LC-MS (n = 10 in each group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 40 |
Tissue | Peripheral; Gut; Colon; Peripheral; Blood; Serum; Central; Brain; Brain; |
Platform | MS-based; LC-MS: Waters Acquity I-CLASS UHPLC with AB QTRPAP-4500; |
PMID | |
DOI | |
Citation | Wang T, Song Y, Ai Z, et al. Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism. Phytomedicine. 2023 Jul 25;116:154852. |
Metabolite |
