Study M1081
Study name | Wang TT 2023a |
Title | Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism |
Overall design | The aim of this study was to determine whether 1-methyl-tryptophan could improve the depression in the chronic unpredictable mild stress (CUMS) model. C57BL/6 J mice were divided into the following 4 groups (n = 10 in each group): (1) control group (non-stress with vehicle treatment), (2) 1-methyl-tryptophan group (non-stress with 1-methyl-tryptophan treatment at a dose of 15 mg/kg/d), (3) CUMS group (stress with vehicle treatment), and (4) CUMS + 1-methyl-tryptophan group (stress with 1-methyl-tryptophan treatment at a dose of 15 mg/kg/d). The CUMS stress procedure lasted for 6 weeks. Measurement of tryptophan and its metabolites levels were performed using LC-MS (n = 10 in each group). |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 40 |
Tissue | Central; Brain; Brain; Peripheral; Gut; Colon; Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity I-CLASS UHPLC with AB QTRPAP-4500; |
PMID | |
DOI | |
Citation | Wang T, Song Y, Ai Z, et al. Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism. Phytomedicine. 2023 Jul 25;116:154852. |
Metabolite |
