Study M1075
Study name | Wang CS 2023b |
Title | Targeting PDK2 rescues stress-induced impaired brain energy metabolism |
Overall design | The aim of this study was to identify potential differentially expressed metabolites in the frontal cortex and serum of chronic social defeat stress (CSDS) mice model of depression. C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) CSDS group. The CSDS stress procedure lasted for 10 days. Frontal cortex and serum samples were used for metabonomic analysis (n = 12/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test, sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Central; Brain; Frontal cortex; Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Wang C, Cui C, Xu P, et al. Targeting PDK2 rescues stress-induced impaired brain energy metabolism. Mol Psychiatry. 2023 May 15. |
Metabolite | myo-Inositol; Citric acid; Oleic acid; Stearic acid; Myristic acid; Palmitic acid; L-Phenylalanine; L-Tryptophan; L-Glutamic acid; Glycine; |
