Study M1071
Study name | Sato S 2023 |
Title | Decreased beta-hydroxybutyrate and ketogenic amino acid levels in depressed human adults |
Overall design | The aim of this study was to evaluate plasma beta-hydroxybutyrate and ketogenic and glucogenic amino acid levels in adult humans with or without depressive symptoms in a large cohort using nuclear magnetic resonance (NMR) spectroscopy. For participants, a CES-D score < 16 is considered healthy (control group, n = 18,150), and a score >= 16 points is considered to indicate a depressive state (depression group, n = 5,722). NMR-based human plasma metabolomics was performed. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | CES-D score >= 16 |
Sample size | 23872 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker Avance 600 MHz spectrometer; |
PMID | |
DOI | |
Citation | Sato S, Yu Z, Sakai M, et al. Decreased beta-hydroxybutyrate and ketogenic amino acid levels in depressed human adults. Eur J Neurosci. 2023 Mar;57(6):1018-1032. |
Metabolite |
