Study M1066
Study name | Liu XJ 2023a |
Title | Gut microbiome and tissue metabolomics reveal the compatibility effects of Xiaoyaosan on depression based on "gut-liver-kidney" axis |
Overall design | The aim of this study was to reveal the compatibility of Xiaoyaosan from the perspective of “gut-liver-kidney” axis in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 5 groups: (1) control group, (2) CUMS group, (3) CUMS + Xiaoyaosan group (stressor plus Xiaoyaosan treatment (4) CUMS + Shugan group (stressor plus Shugan treatment), and (5) CUMS + Jianpi group (stressor plus Jianpi treatment). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric during the model building period. Kidney tissues were analyzed by NMR-based metabolomics (n = 6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 30 |
Tissue | Peripheral; Kidney; Kidney; |
Platform | NMR; NMR: Bruker 600 MHz AVANCENMR III NMR spectrometer; |
PMID | |
DOI | |
Citation | Liu X, Wu X, Wang S, et al. Gut microbiome and tissue metabolomics reveal the compatibility effects of Xiaoyaosan on depression based on "gut-liver-kidney" axis. Phytomedicine. 2023 Mar;111:154628. |
Metabolite | L-Leucine; L-Glutamic acid; |
