Study M1063
Study name | Liu JC 2023 |
Title | A preliminary comparison of plasma tryptophan metabolites and medium- and long-chain fatty acids in adult patients with major depressive disorder and schizophrenia |
Overall design | The aim of this study was to determine the differences in tryptophan metabolites and the composition of medium- and long-chain fatty acids in adult patients with major depressive disorder (MDD) and schizophrenia. Metabolite levels in plasma samples from patients with MDD (MDD group, n = 24) and healthy controls (control group, n = 23) were analyzed. Tryptophan and its catabolites were detected by liquid chromatography-mass spectrometry, and medium and long-chain fatty acids were detected by gas chromatography-mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 47 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity UHPLC system with 5500 QTRAP mass spectrometer (AB SCIEX); MS-based; GC-MS: Agilent 7890/5975C GC-MS; |
PMID | |
DOI | |
Citation | Liu JC, Yu H, Li R, et al. A preliminary comparison of plasma tryptophan metabolites and medium- and long-chain fatty acids in adult patients with major depressive disorder and schizophrenia. Medicina (Kaunas). 2023 Feb 20;59(2):413. |
Metabolite | L-Tryptophan; 5-Hydroxyindoleacetic acid; Indoleacetic acid; Indolelactic acid; Docosahexaenoic acid; Caprylic acid; Dodecanoic acid; Capric acid; Docosapentaenoic acid (22n-3); Gamma-Linolenic acid; Indole; Myristoleic acid; Erucic acid; Indole-3-carboxaldehyde; |
