Study M1053
Study name | Jia SQ 2023 |
Title | Quercetin modulates the liver metabolic profile in a chronic unpredictable mild stress rat model based on metabolomics technology |
Overall design | The aim of this study was to explore the protective effect of quercetin against chronic unpredictable mild stress (CUMS)-induced metabolic changes and the corresponding mechanisms in the rat liver based on untargeted metabolomics technology. Sprague-Dawley rats were divided into the following 4 groups (n = 16 in each group): (1) control group (no stress, with vehicle treatment), (2) CUMS group (stress, with vehicle treatment), (3) quercetin group (no stress, with quercetin treatment), and (4) CUMS + quercetin group (stress, with quercetin treatment). The CUMS stress procedure lasted for 8 weeks, and quercetin (50 mg/kg) was administered via intragastric once per day during the model building period. Liver samples (n = 10/per group) were collected for untargeted metabolomics analysis. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 40 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC System with tandem mass spectrometry; |
PMID | |
DOI | |
Citation | Jia S, Wang R, Zhang D, et al. Quercetin modulates the liver metabolic profile in a chronic unpredictable mild stress rat model based on metabolomics technology. Food Funct. 2023 Feb 6;14(3):1726-1739. |
Metabolite | L-Methionine; Cholic acid; S-Adenosylhomocysteine; Taurochenodesoxycholic acid; Deoxycholic acid; L-Homocystine; Folic acid; Prostaglandin E2; PE(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PC(16:0/P-18:0); S-Adenosylmethionine; Lithocholic acid glycine conjugate; |
