Study M1045
Study name | Liu Y 2022 |
Title | Systematic metabolic characterization of mental disorders reveals age-related metabolic disturbances as potential risk factors for depression in older adults |
Overall design | The aim of this study was to reveal the metabolic risk factors for anxiety, depression, and comorbid anxiety-depressive disorder in older adults. Geriatric Depression Scale-15 (GDS-15) and General Anxiety Disorder-7 (GAD) were used to rate depression and anxiety symptoms. A total of 248 participants, including 41 individuals with comorbid anxiety and depression (anxiety and depression group; GAD score > 5 and GDS score > 5), 52 persons with depression (depression group; only GDS score > 5), 55 cases with anxiety (anxiety group; only GAD score > 5), and 100 control participants (control group; GDS score and GAD score are less than 1) were included. Metabolomics and lipidomics analyses were performed to profile the plasma metabolome associated with anxiety, depression, and comorbid anxiety-depressive disorder. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Geriatric Depression Scale-15 > 5 |
Sample size | 193 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Liu Y, Zhao W, Lu Y, et al. Systematic metabolic characterization of mental disorders reveals age-related metabolic disturbances as potential risk factors for depression in older adults. MedComm. 2022 Sep 30;3(4):e165. |
Metabolite | Linoleic acid; Stearic acid; Palmitoleic acid; L-Phenylalanine; Uridine; L-Cystine; L-Kynurenine; D-Arabinose; Cholic acid; Oxoglutaric acid; Homogentisic acid; 5-Methoxytryptophol; Uracil; Creatine; Hypotaurine; L-Histidine; Docosahexaenoic acid; L-Malic acid; 1-Methylnicotinamide; Aminoadipic acid; N-Acetyl-L-alanine; Glycerol 3-phosphate; p-Cresol sulfate; L-Alpha-aminobutyric acid; D-Arabitol; Guanidinosuccinic acid; 5-Hydroxy-L-tryptophan; Dehydroepiandrosterone sulfate; Asymmetric dimethylarginine; Docosapentaenoic acid (22n-3); Galactitol; N-Acetylneuraminic acid; Coprocholic acid; N-Acetylserine; N-Formyl-L-methionine; Ergothioneine; N-alpha-Acetyl-L-lysine; Deoxyribose; N-Acetyl-L-methionine; 3-Hydroxyisovaleric acid; Acetylglycine; Val-Pro/pro-val; L-Erythrulose; Cer(d34:1); Asp-Gly/Gly-Asp; |
