Study M1044
Study name | Liu XJ 2023b |
Title | Microbiome and metabolome reveal the metabolic and microbial variations induced by depression and constipation |
Overall design | The aim of this study was to reveal the possible correlations between depression and constipation from the perspectives of gut microbiome and plasma metabolome. Chronic unpredictable mild stress (CUMS) and the constipated model were constructed. Sprague-Dawley rats were divided into the following 2 groups (n = 6 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Nuclear magnetic resonance metabolomics was applied to reveal altered metabolites in the plasma. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 12 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu X, Zhao Z, Fan Y, et al. Microbiome and metabolome reveal the metabolic and microbial variations induced by depression and constipation. Psychogeriatrics. 2023 Mar;23(2):319-336. |
Metabolite |
